Organized chaos in the enzyme complex—surprising insights and new perspectives
For protein molecules that contribute to metabolism, interactions with other components of their metabolic pathway can be crucial. Scientists at the Max Planck Institute for Developmental Biology in Tübingen have now investigated a natural enzyme complex that comprises 10 enzymes with five distinct activities. They found that the molecular architecture is surprisingly compact, yet offers individual enzymes maximum free moving space, which opens up novel perspectives for drug discovery. The scientists have published their results in Nature Chemical Biology.