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theedadvocate.orgClosing the computer science gender gap: How one woman is making a difference in many lives - The EdvocateSpread the love**The Edvocate is pleased to publish guest posts as way to fuel important conversations surrounding P-20 education in America. The opinions contained within guest posts are those of the authors and do not necessarily reflect the official opinion of The Edvocate or Dr. Matthew Lynch.** Maria Klawe, Harvey Mudd College I’ve been passionate about increasing women’s participation in computer science for more than 25 years. While the number of undergraduate women pursuing some STEM (science, technology, engineering, math) fields like biology and chemistry has steadily increased over the past couple of decades, women’s participation in computer science (CS) has …1
theedadvocate.orgBlack Boys in Crisis: Teachers, the Good and the Appalling - The EdvocateSpread the loveIn this series, appropriately titled “Black Boys in Crisis,” I highlight the problems facing black boys in education today, as well as provide clear steps that will lead us out of the crisis. One of the most influential teachers I had was my high school biology teacher, Mrs. Minor. She was the wife of my former elementary school principal, and mother to one of my classmates. Mrs. Minor approached her job as a teacher from the standpoint of love and caring. She recognized that, for many of us, her smile was the only one we would see each …
phys.orgTeam makes breakthrough in synthetic genome rearrangementA synthetic biology team at Tianjin University (TJU) has reported new methods and strategies for genome rearrangement and accelerated the evolution of yeast strains with their three latest studies published in Nature Communications on May 22, 2018.
amazon.comA Coloring Book for TeachersA Coloring Book for Teachers is an affordable gift to help your teachers relax! From reminiscing to their first time on a school bus to doodling your way through biology - this makes school fun for everyone! Inside you'll find pages on: Science, Lunch, School Supplies, School Bus, Art, Biology, M...1
thetechedvocate.orgClosing the computer science gender gap: How one woman is making a difference in many livesSpread the love**The Edvocate is pleased to publish guest posts as way to fuel important conversations surrounding P-20 education in America. The opinions contained within guest posts are those of the authors and do not necessarily reflect the official opinion of The Edvocate or Dr. Matthew Lynch.** Maria Klawe, Harvey Mudd College I’ve been passionate about increasing women’s participation in computer science for more than 25 years. While the number of undergraduate women pursuing some STEM (science, technology, engineering, math) fields like biology and chemistry has steadily increased over the past couple of decades, women’s participation in computer science (CS) has …
phys.orgRevealing the mysteries of early developmentZebrafish embryos are transparent and develop outside the mother's body, enabling scientists to get a detailed view of early development. A research team led by Lila Solnica-Krezel, the Alan A. and Edith L. Wolff Distinguished Professor and head of the Department of Developmental Biology at Washington University School of Medicine in St. Louis, is revealing new clues to how birth defects develop in the tiniest embryos. Solnica-Krezel explained her lab's recent work, published in the journal Developmental Cell.
theedadvocate.orgQueering Campuses Prompts Reflection, Reform for Universities - The EdvocateSpread the loveNote: The following guest post comes to us courtesy of Jacob Bell, a junior at the University of Maryland pursuing a dual degree in journalism and general biology. He currently works as the staff writer and web content manager for Student Voice and is a general assignment reporter for the University of Maryland’s student newspaper, The Diamondback. Jacob is also the features chair of “Stories Beneath the Shell,” which is an online multimedia publication. You can learn more about Jacob by connecting with him through LinkedIn or following him on Twitter, @realjacobbell. The word ‘queer’ can mean many …
jalopnik.comMustang Moron Blocks Traffic To Do Donuts On A CausewayDoing donuts in a car is one of the highest forms of humankind’s interactions with the physical world. It’s a delicate dance of form and shape, of machine and biology, of rubber and asphalt. That said, if you do them in the middle of a busy bridge and cause an enormous traffic jam, you’re a jackass who’s going to ruin it for everybody. Like these dipshits in (of course) Ft. Lauderdale, Florida.
themindcircle.comThe Incredible Return of The Bald Eagle's Population In The State Of VirginiaAn incredible 1,070 bald eagles' nests were surveyed by the Center of Conservation Biology conducted at William and Mary College. This is the highest number since the survey began 60 years ago. It is believed the number has grown thanks to the ban on pesticides. This incredible comeback in the population of the bald
pnas.orgTemporal transcriptional logic of dynamic regulatory networks underlying nitrogen signaling and use in plantsOur study exploits time—the relatively unexplored fourth dimension of gene regulatory networks (GRNs)—to learn the temporal transcriptional logic underlying dynamic nitrogen (N) signaling in plants. We introduce several conceptual innovations to the analysis of time-series data in the area of predictive GRNs. Our resulting network now provides the “transcriptional logic” for transcription factor perturbations aimed at improving N-use efficiency, an important issue for global food production in marginal soils and for sustainable agriculture. More broadly, the combination of the time-based approaches we develop and deploy can be applied to uncover the temporal “transcriptional logic” for any response system in biology, agriculture, or medicine. This study exploits time, the relatively unexplored fourth dimension of gene regulatory networks (GRNs), to learn the temporal transcriptional logic underlying dynamic nitrogen (N) signaling in plants. Our “just-in-time” analysis of time-series transcriptome data uncovered a temporal cascade of cis elements underlying dynamic N signaling. To infer transcription factor (TF)-target edges in a GRN, we applied a time-based machine learning method to 2,174 dynamic N-responsive genes. We experimentally determined a network precision cutoff, using TF-regulated genome-wide targets of three TF hubs (CRF4, SNZ, and CDF1), used to “prune” the network to 155 TFs and 608 targets. This network precision was reconfirmed using genome-wide TF-target regulation data for four additional TFs (TGA1, HHO5/6, and PHL1) not used in network pruning. These higher-confidence edges in the GRN were further filtered by independent TF-target binding data, used to calculate a TF “N-specificity” index. This refined GRN identifies the temporal relationship of known/validated regulators of N signaling (NLP7/8, TGA1/4, NAC4, HRS1, and LBD37/38/39) and 146 additional regulators. Six TFs—CRF4, SNZ, CDF1, HHO5/6, and PHL1—validated herein regulate a significant number of genes in the dynamic N response, targeting 54% of N-uptake/assimilation pathway genes. Phenotypically, inducible overexpression of CRF4 in planta regulates genes resulting in altered biomass, root development, and 15NO3− uptake, specifically under low-N conditions. This dynamic N-signaling GRN now provides the temporal “transcriptional logic” for 155 candidate TFs to improve nitrogen use efficiency with potential agricultural applications. Broadly, these time-based approaches can uncover the temporal transcriptional logic for any biological response system in biology, agriculture, or medicine.
phys.orgComputer redesigns enzymeUniversity of Groningen biotechnologists used a computational method to redesign aspartase and convert it to a catalyst for asymmetric hydroamination reactions. Their colleagues in China scaled up the production of this enzyme and managed to produce kilograms of very pure building blocks for pharmaceuticals and other bioactive compounds. This successful proof of principle study was published in Nature Chemical Biology on 21 May.